Study Ties Saturated Fat to Alzheimer’s Risk

brainfood1A recent study found that dietary saturated fat cut the body’s levels of a key chemical—apolipoprotein E (ApoE)—that helps protect against Alzheimer’s disease.

Study participants who received a high-saturated-fat, high-sugar diet showed a change in their ApoE that made it less able to help clear the amyloid. If left loose in the brain, amyloid beta proteins are more likely to form plaques that interfere with neuron function, the kind of plaques found in the brains of people with Alzheimer’s disease.

Diet also directly affected the amount of loose amyloid beta found in cerebrospinal fluid. People on a high-saturated-fat diet had higher levels of amyloid beta in their spinal fluid, while people on a low-saturated-fat diet actually saw a decline in such levels.

While this study is preliminary, it adds another small piece to the growing evidence that taking good care of your heart is probably good for your brain too. We tend to focus on diet in terms of weight and heart health, but often overlook that diet is critical for healthy brain aging. In addition, many of the things the brain needs to function properly—fatty acids and certain amino acids, for example—come only from food.

People focus on diet in terms of weight and heart health, but they overlook that nutrition can be key to cognitive function as well. According to research team member Suzanne Craft, a professor of medicine at Wake Forest School of Medicine, “Diet is a very underappreciated factor in terms of brain function. It’s quite well accepted for your heart and your cholesterol and your blood, but diet is also critical for a healthy brain aging. Many of the things the brain needs to function properly—fatty acids, certain amino acids— come only from food.”

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